Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Predicting the functional consequences of non-synonymous single nucleotide polymorphisms in IL8 gene.

Scientific reports - 26 Jul 2017

Dakal Tikam Chand, Kala Deepak, Dhiman Gourav, Yadav Vinod, Krokhotin Andrey, Dokholyan Nikolay V

Abstract excerpt

Here we report an in-silico approach for identification, characterization and validation of deleterious non-synonymous SNPs (nsSNPs) in the interleukin-8 gene using three steps. In first step, sequence homology-based genetic analysis of a set of 50 coding SNPs associated with 41 rsIDs using SIFT (Sorting Intolerant from Tolerant) and PROVEAN (Protein Variation Effect Analyzer) identified 23 nsSNPs to be...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Substitution
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-8

Share to Lung Neoplasms

Share to Polymorphism, Single Nucleotide

Share to Stomach Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 28747718
DOI: 10.1038/s41598-017-06575-4
PMCID: PMC5529537

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Predicting the functional consequences of non-synonymous single nucleotide polymorphisms in IL8 gene.PMID 28747718Read ↗

Computational insight in the identification of nonsynonymous single nucleotide polymorphism affecting the structure and function of Interleukin-4Semantic proximity Read ↗

Computational Insight in the Identification of Non-Synonymous Single-Nucleotide Polymorphism Affecting the Structure and Function of Interleukin-4.Semantic proximity Read ↗

In-silico analysis unravels the structural and functional consequences of non-synonymous SNPs in the human IL-10 geneSemantic proximity Read ↗

Prediction of the most deleterious non-synonymous SNPs in the human IL1B gene: evidence from bioinformatics analyses.Semantic proximity Read ↗

A comprehensive in Silico analysis of the functional and structural impact of single nucleotide polymorphisms (SNPs) in the human IL-33 gene.Semantic proximity Read ↗

Predicting deleterious amino acid substitutions.Semantic proximity Read ↗

Applications of computational algorithm tools to identify functional SNPs in cytokine genes.Semantic proximity Read ↗

Insilico prediction and functional analysis of nonsynonymous SNPs in human CTLA4 gene.Semantic proximity Read ↗

Demystifying the implications of disease-susceptible missense SNPs within CTLA-4 ligand binding domain and its interaction towards B7-1 protein complex: Bioinformatics-driven evidence.Semantic proximity Read ↗

Phenotype prediction of deleterious nonsynonymous single nucleotide polymorphisms in human alcohol metabolism-related genes: a bioinformatics study.Semantic proximity Read ↗

Prediction of deleterious non-synonymous SNPs based on protein interaction network and hybrid properties.Semantic proximity Read ↗

In Silico Identification and Structural Characterization of High-Risk Missense SNVs in the Human IL23R Gene Relevant to Inflammatory Bowel Disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.