Demystifying the implications of disease-susceptible missense SNPs within CTLA-4 ligand binding domain and its interaction towards B7-1 protein complex: Bioinformatics-driven evidence.

Abstract excerpt

Alteration of a nucleotide within a triplet codon results in substitution of a different amino acid in the protein sequence, collectively termed as missense or non-synonymous Single-Nucleotide Polymorphisms (nsSNPs). Cytoplasmic T Lymphocytes Antigen-4 (CTLA-4) gene encodes a transmembrane protein expressed on activated T cells. CTLA-4 receptor acts as an immunoregulatory molecule that prompts immunological...

Topics

Join the communities discussing this publication.

• B7-1 Antigen
• Computational Biology
• CTLA-4 Antigen
• Ligands
• Molecular Docking Simulation