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Article

Prediction of the most deleterious non-synonymous SNPs in the human IL1B gene: evidence from bioinformatics analyses.

BMC genomic data - 10 Jun 2024

Abuzaid Ola, Idris Abeer Babiker, Yılmaz Semih, Idris Einass Babikir, Idris Leena Babiker, Hassan Mohamed A

Abstract excerpt

BACKGROUND: Polymorphisms in IL1B play a significant role in depression, multiple inflammatory-associated disorders, and susceptibility to infection. Functional non-synonymous SNPs (nsSNPs) result in changes in the encoded amino acids, potentially leading to structural and functional alterations in the mutant proteins. So far, most genetic studies have concentrated on SNPs located in the IL1B promoter region,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38858637
DOI: 10.1186/s12863-024-01233-x
PMCID: PMC11163699

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