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Article

In Silico Identification and Structural Characterization of High-Risk Missense SNVs in the Human IL23R Gene Relevant to Inflammatory Bowel Disease.

Genes - 16 Jun 2026

Altintas Kazar Gamze

Abstract excerpt

BACKGROUND/OBJECTIVES: IL23R encodes a pivotal component of the IL-23/Th17 signaling axis and represents a validated genetic susceptibility locus for inflammatory bowel disease (IBD), psoriasis, and ankylosing spondylitis. Despite extensive GWAS data, the functional consequences of the full spectrum of IL23R missense single-nucleotide variants (SNVs) have not been systematically characterized. This study aimed to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

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Share to Mutation, Missense

Share to Polymorphism, Single Nucleotide

Share to Receptors, Interleukin

Source

Open in PubMed Open full text

Identifiers

PMID: 42353858
DOI: 10.3390/genes17060699
PMCID: PMC13299892

Genes

IL23R
IL12B
IL12RB1
IL23A
JAK2
STAT3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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In Silico Identification and Structural Characterization of High-Risk Missense SNVs in the Human IL23R Gene Relevant to Inflammatory Bowel Disease.PMID 42353858Read ↗

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