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Article

Insilico prediction and functional analysis of nonsynonymous SNPs in human CTLA4 gene.

Scientific reports - 28 Nov 2022

Irfan Muhammad, Iqbal Talha, Hashmi Sakina, Ghani Uzma, Bhatti Attya

Abstract excerpt

The CTLA4 receptor is an immune checkpoint involved in the downregulation of T cells. Polymorphisms in this gene have been found to be associated with different diseases like rheumatoid arthritis, autosomal dominant immune dysregulation syndrome, juvenile idiopathic arthritis and autoimmune Addison's disease. Therefore, the identification of polymorphisms that have an effect on the structure and function of CTLA4...

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Identifiers

PMID: 36443461
DOI: 10.1038/s41598-022-24699-0
PMCID: PMC9705290

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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