Article
Phenotype prediction of deleterious nonsynonymous single nucleotide polymorphisms in human alcohol metabolism-related genes: a bioinformatics study.
Alcohol (Fayetteville, N.Y.) - 1 Aug 2010
Wang Lin-Lin, Yang An-Kui, Li Yong, Liu Jun-Ping, Zhou Shu-Feng
Abstract excerpt
Nonsynonymous single nucleotide polymorphisms (nsSNPs) are thought as potential disease modifiers because they alter the encoded amino acid sequence and are likely to affect the function of the proteins accounting for susceptibility to disease. Distinguishing the functionally significant nsSNPs from tolerant nsSNPs is helpful to characterize the genetic basis of human diseases and assess individual susceptibility...
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