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Article

Prediction of deleterious non-synonymous SNPs based on protein interaction network and hybrid properties.

PloS one - 30 Jul 2010

Huang Tao, Wang Ping, Ye Zhi-Qiang, Xu Heng, He Zhisong, Feng Kai-Yan, Hu Lele, Cui Weiren, Wang Kai, Dong Xiao, Xie Lu, Kong Xiangyin, Cai Yu-Dong, Li Yixue

Abstract excerpt

Non-synonymous SNPs (nsSNPs), also known as Single Amino acid Polymorphisms (SAPs) account for the majority of human inherited diseases. It is important to distinguish the deleterious SAPs from neutral ones. Most traditional computational methods to classify SAPs are based on sequential or structural features. However, these features cannot fully explain the association between a SAP and the observed...

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PMID: 20689580
DOI: 10.1371/journal.pone.0011900
PMCID: PMC2912763

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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