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Article

Porcine familial adenomatous polyposis model enables systematic analysis of early events in adenoma progression.

Scientific reports - 26 Jul 2017

Flisikowska Tatiana, Stachowiak Monika, Xu Hongen, Wagner Alexandra, Hernandez-Caceres Alejandra, Wurmser Christine, Perleberg Carolin, Pausch Hubert, Perkowska Anna, Fischer Konrad, Frishman Dmitrij, Fries Ruedi, Switonski Marek, Kind Alexander, Saur Dieter, Schnieke Angelika, Flisikowski Krzysztof

Abstract excerpt

We compared gene expression in low and high-grade intraepithelial dysplastic polyps from pigs carrying an APC 1311 truncating mutation orthologous to human APC 1309 , analysing whole samples and microdissected dysplastic epithelium. Gene set enrichment analysis revealed differential expression of gene sets similar to human normal mucosa versus T1 stage polyps. Transcriptome analysis of whole samples revealed many...

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Source

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Identifiers

PMID: 28747659
DOI: 10.1038/s41598-017-06741-8
PMCID: PMC5529429

Genes

APC
GBP6
PLXND1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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