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<i>Smad4</i> and TGF-β1 dependent gene expression biomarkers in conditional intestinal adenoma, organoids and colorectal cancer

2024-03-19

Abstract excerpt

TGF-β ligand activation suppresses cell growth yet can paradoxically and potently promote cancer invasion and metastasis depending on downstream pathway mutational context. Here, we evaluated the basis of this observation in conditional murine intestinal adenoma models with and without loss of Mothers against decapentaplegic homolog 4 ( Smad4 ), with the aim of identifying TGF-β-BMP-SMAD4 pathway dependent gene e...

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Literature Corpus work
d5033e03-7a2b-5a8d-81e7-2e9a5545e078
DOI
10.1101/2024.03.15.584288
Open publication

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<i>Smad4</i> and TGF-β1 dependent gene expression biomarkers in conditional intestinal adenoma, organoids and colorectal cancerDOI 10.1101/2024.03.15.584288
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