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A LGR5 reporter pig model closely resembles human intestine for improved study of stem cells in disease

9 May 2023

Abstract excerpt

Abstract Intestinal epithelial stem cells (ISCs) are responsible for intestinal epithelial barrier renewal; thereby, ISCs play a critical role in intestinal pathophysiology research. While transgenic ISC reporter mice are available, advanced translational studies lack a large animal model. This study validates ISC isolation in a new porcine Leucine Rich Repeat Containing G Protein‐Coupled Receptor 5 (LGR5)...

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PMID: 37159340
DOI: 10.1096/fj.202300223r

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