Article
A porcine model of familial adenomatous polyposis.
Gastroenterology - 1 Nov 2012
Flisikowska Tatiana, Merkl Claudia, Landmann Martina, Eser Stefan, Rezaei Nousin, Cui Xinxin, Kurome Mayuko, Zakhartchenko Valeri, Kessler Barbara, Wieland Hagen, Rottmann Oswald, Schmid Roland M, Schneider Günter, Kind Alexander, Wolf Eckhard, Saur Dieter, Schnieke Angelika
Abstract excerpt
We created gene-targeted pigs with mutations in the adenomatous polyposis coli (APC) gene (APC) that are orthologous to those responsible for human familial adenomatous polyposis (FAP). One-year-old pigs with the APC(1311) mutation (orthologous to human APC(1309)) have aberrant crypt foci and low- and high-grade dysplastic adenomas in the large intestine, similar to the precancerous lesions that develop in...
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