Article
Cross-species comparison of human and mouse intestinal polyps reveals conserved mechanisms in adenomatous polyposis coli (APC)-driven tumorigenesis.
The American journal of pathology - 1 May 2008
Gaspar Claudia, Cardoso Joana, Franken Patrick, Molenaar Lia, Morreau Hans, Möslein Gabriela, Sampson Julian, Boer Judith M, de Menezes Renée X, Fodde Riccardo
Abstract excerpt
Expression profiling is a well established tool for the genome-wide analysis of human cancers. However, the high sensitivity of this approach combined with the well known cellular and molecular heterogeneity of cancer often result in extremely complex expression signatures that are difficult to interpret functionally. The majority of sporadic colorectal cancers are triggered by mutations in the adenomatous...
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