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Article

Evidence for dynein and astral microtubule-mediated cortical release and transport of Gαi/LGN/NuMA complex in mitotic cells.

Molecular biology of the cell - 1 Apr 2013

Zheng Zhen, Wan Qingwen, Liu Jing, Zhu Huabin, Chu Xiaogang, Du Quansheng

Abstract excerpt

Spindle positioning is believed to be governed by the interaction between astral microtubules and the cell cortex and involve cortically anchored motor protein dynein. How dynein is recruited to and regulated at the cell cortex to generate forces on astral microtubules is not clear. Here we show that mammalian homologue of Drosophila Pins (Partner of Inscuteable) (LGN), a Gαi-binding protein that is critical for...

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Source

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Identifiers

PMID: 23389635
DOI: 10.1091/mbc.E12-06-0458
PMCID: PMC3608500

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Evidence for dynein and astral microtubule-mediated cortical release and transport of Gαi/LGN/NuMA complex in mitotic cells.PMID 23389635Read ↗

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