Article
Association Between Substance Use Disorder and Polygenic Liability to Schizophrenia.
Biological psychiatry - 15 Nov 2017
Hartz Sarah M, Horton Amy C, Oehlert Mary, Carey Caitlin E, Agrawal Arpana, Bogdan Ryan, Chen Li-Shiun, Hancock Dana B, Johnson Eric O, Pato Carlos N, Pato Michele T, Rice John P, Bierut Laura J
Abstract excerpt
BACKGROUND: There are high levels of comorbidity between schizophrenia and substance use disorder, but little is known about the genetic etiology of this comorbidity. METHODS: We tested the hypothesis that shared genetic liability contributes to the high rates of comorbidity between schizophrenia and substance use disorder. To do this, polygenic risk scores for schizophrenia derived from a large meta-analysis by...
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