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Article

Genetic Relationship between Schizophrenia and Nicotine Dependence.

Scientific reports - 10 May 2016

Chen Jingchun, Bacanu Silviu-Alin, Yu Hui, Zhao Zhongming, Jia Peilin, Kendler Kenneth S, Kranzler Henry R, Gelernter Joel, Farrer Lindsay, Minica Camelia, Pool Rene, Milaneschi Yuri, Boomsma Dorret I, Penninx Brenda W J H, Tyndale Rachel F, Ware Jennifer J, Vink Jacqueline M, Kaprio Jaakko, Munafò Marcus, Chen Xiangning

Abstract excerpt

It is well known that most schizophrenia patients smoke cigarettes. There are different hypotheses postulating the underlying mechanisms of this comorbidity. We used summary statistics from large meta-analyses of plasma cotinine concentration (COT), Fagerström test for nicotine dependence (FTND) and schizophrenia to examine the genetic relationship between these traits. We found that schizophrenia risk scores...

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Source

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Identifiers

PMID: 27164557
DOI: 10.1038/srep25671
PMCID: PMC4862382

Genes

CPD
ENOX1
MANBA
MTRF1
RANGAP1
RBFOX1
TINCR
XYLB

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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