Article
Examining the role of common genetic variants on alcohol, tobacco, cannabis and illicit drug dependence: genetics of vulnerability to drug dependence.
Addiction (Abingdon, England) - 1 Mar 2015
Palmer Rohan H C, Brick Leslie, Nugent Nicole R, Bidwell L Cinnamon, McGeary John E, Knopik Valerie S, Keller Matthew C
Abstract excerpt
BACKGROUND AND AIMS: Twin and family studies suggest that genetic influences are shared across substances of abuse. However, despite evidence of heritability, genome-wide association and candidate gene studies have indicated numerous markers of limited effects, suggesting that much of the heritability remains missing. We estimated (1) the aggregate effect of common single nucleotide polymorphisms (SNPs) on...
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