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Article

Investigating the polygenic relationship between heavy cannabis use and schizophrenia in the All of Us Research Program.

Psychological medicine - 17 Dec 2025

Austin-Zimmerman Isabelle, Thorpe Hayley H A, Meredith John J, Khokhar Jibran Y, Ge Tian, Di Forti Marta, Agrawal Arpana, Johnson Emma C, Sanchez-Roige Sandra

Abstract excerpt

BACKGROUND: Decades of research have identified a strong association between heavy cannabis use and schizophrenia (SCZ), with evidence of correlated genetic factors. However, many studies on the genetic relationship between cannabis use and psychosis have lacked data on both phenotypes within the same individuals, creating challenges due to unmeasured confounding. We aimed to address this by using multimodal data...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41403271
DOI: 10.1017/S0033291725102717
PMCID: PMC13058615

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