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Article

Shared genetic effects among schizophrenia, substance use disorder, and hippocampal volume in a multiplex extended pedigree sample.

Schizophrenia research - 1 Jan 2026

Musket Christie W, Rupert Petra E, Kuo Susan S, Roalf David R, Prasad Konasale M, Wood Joel, Gur Ruben C, Almasy Laura A, Gur Raquel E, Nimgaonkar Vishwajit L, Pogue-Geile Michael F

Abstract excerpt

BACKGROUND: Many individuals with schizophrenia have comorbid substance use disorders (SUD) and yet the reasons for this comorbidity are largely unknown. The current study examined if shared genetic effects jointly increase risk for both schizophrenia and SUD and if shared genetic effects on brain structure phenotypes mediate this relationship. METHODS: Data were collected using a multiplex extended pedigree...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41386004
DOI: 10.1016/j.schres.2025.11.014
PMCID: PMC13441064

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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