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Article

Decline in cellular function of aged mouse c‐kit+ cardiac progenitor cells

24 Jul 2017

Abstract excerpt

KEY POINTS: cells from young (3 months) and aged (24 months) C57BL/6 mice to compare their biological properties. Aged CPCs have increased senescence, decreased stemness and reduced capacity to proliferate or to differentiate following dexamethasone (Dex) treatment in vitro, as evidenced by lack of cardiac lineage gene upregulation. Aged CPCs fail to activate mitochondrial biogenesis and increase proteins...

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PMID: 28737214
DOI: 10.1113/jp274775

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