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Restoration of CPEB4 prevents muscle stem cell senescence during aging

15 Jun 2023

Abstract excerpt

Age-associated impairments in adult stem cell functions correlate with a decline in somatic tissue regeneration capacity. However, the mechanisms underlying the molecular regulation of adult stem cell aging remain elusive. Here, we provide a proteomic analysis of physiologically aged murine muscle stem cells (MuSCs), illustrating a pre-senescent proteomic signature. During aging, the mitochondrial proteome and...

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PMID: 37321216
DOI: 10.1016/j.devcel.2023.05.012

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