Article
Activation of cardiac progenitor cells reverses the failing heart senescent phenotype and prolongs lifespan.
Circulation research - 14 Mar 2008
Gonzalez Arantxa, Rota Marcello, Nurzynska Daria, Misao Yu, Tillmanns Jochen, Ojaimi Caroline, Padin-Iruegas M Elena, Müller Patrick, Esposito Grazia, Bearzi Claudia, Vitale Serena, Dawn Buddhadeb, Sanganalmath Santosh K, Baker Mathue, Hintze Thomas H, Bolli Roberto, Urbanek Konrad, Hosoda Toru, Anversa Piero, Kajstura Jan, Leri Annarosa
Abstract excerpt
Heart failure is the leading cause of death in the elderly, but whether this is the result of a primary aging myopathy dictated by depletion of the cardiac progenitor cell (CPC) pool is unknown. Similarly, whether current lifespan reflects the ineluctable genetic clock or heart failure interferes with the genetically determined fate of the organ and organism is an important question. We have identified that...
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