Article
Accumulation of Mitochondrial DNA Mutations Disrupts Cardiac Progenitor Cell Function and Reduces Survival.
The Journal of biological chemistry - 4 Sept 2015
Orogo Amabel M, Gonzalez Eileen R, Kubli Dieter A, Baptista Igor L, Ong Sang-Bing, Prolla Tomas A, Sussman Mark A, Murphy Anne N, Gustafsson Åsa B
Abstract excerpt
Transfer of cardiac progenitor cells (CPCs) improves cardiac function in heart failure patients. However, CPC function is reduced with age, limiting their regenerative potential. Aging is associated with numerous changes in cells including accumulation of mitochondrial DNA (mtDNA) mutations, but it is unknown how this impacts CPC function. Here, we demonstrate that acquisition of mtDNA mutations disrupts...
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