Article
Molecular signature of progenitor cells isolated from young and adult human hearts.
Scientific reports - 18 Jun 2018
Walravens Ann-Sophie, Vanhaverbeke Maarten, Ottaviani Lara, Gillijns Hilde, Trenson Sander, Driessche Nina Vanden, Luttun Aernout, Meyns Bart, Herijgers Paul, Rega Filip, Heying Ruth, Sampaolesi Maurilio, Janssens Stefan
Abstract excerpt
The loss of endogenous cardiac regenerative capacity within the first week of postnatal life has intensified clinical trials to induce cardiac regeneration in the adult mammalian heart using different progenitor cell types. We hypothesized that donor age-related phenotypic and functional characteristics of cardiac progenitor cells (CPC) account for mixed results of cell-based cardiac repair. We compared...
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