Back to search

Article

Aged-senescent cells contribute to impaired heart regeneration

2018-08-21

Abstract excerpt

Aging leads to increased cellular senescence and is associated with decreased potency of tissue-specific stem/progenitor cells. Here we have done an extensive analysis of cardiac progenitor cells (CPCs) isolated from human subjects with cardiovascular disease (n=119), aged 32-86 years. In aged subjects (>74 years old) over half of CPCs are senescent (p16 INK4A , SA-β-gal, DNA damage γH2AX, telomere length, Senesc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
827c36e1-62fb-562b-929c-9762a41c53e3
DOI
10.1101/397216
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Aged-senescent cells contribute to impaired heart regenerationDOI 10.1101/397216
Cellular senescence in cardiac diseasesSemantic proximity
Targeting Cardiac Stem Cell Senescence to Treat Cardiac Aging and DiseaseSemantic proximity
Therapeutic opportunities for senolysis in cardiovascular diseaseSemantic proximity
Activation of cardiac progenitor cells reverses the failing heart senescent phenotype and prolongs lifespan.Semantic proximity
Senolytic-Resistant Senescent Cells Have a Distinct SASP Profile and Functional Impact: The Path to Developing SenosensitizersSemantic proximity
Cellular senescence and cardiovascular diseases: moving to the “heart” of the problemSemantic proximity
Senescent cell heterogeneity and responses to senolytic treatment are related to cell cycle status during senescence inductionSemantic proximity
Senescent Cells: A Novel Therapeutic Target for Aging and Age-Related DiseasesSemantic proximity
Senescent cell heterogeneity and responses to senolytic treatment are related to cell cycle status during cell growth arrestSemantic proximity
Cellular Senescence and Senescence-Associated Secretory Phenotype Drive Multipotent Cardiac Stem/Progenitor Cell Dysfunction in Human Diabetic Cardiomyopathy Independently of AgeSemantic proximity
Length-independent telomere damage drives cardiomyocyte senescenceSemantic proximity
From the divergence of senescent cell fates to mechanisms and selectivity of senolytic drugsSemantic proximity
Select a neighboring publication to make it the new centre.