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Article

Clonal composition of human ovarian cancer based on copy number analysis reveals a reciprocal relation with oncogenic mutation status.

Cancer letters - 1 Oct 2017

Sakai Kazuko, Ukita Masayo, Schmidt Jeanette, Wu Longyang, De Velasco Marco A, Roter Alan, Jevons Luis, Nishio Kazuto, Mandai Masaki

Abstract excerpt

Intratumoral heterogeneity of cancer cells remains largely unexplored. Here we investigated the composition of ovarian cancer and its biological relevance. A whole-genome single nucleotide polymorphism array was applied to detect the clonal composition of 24 formalin-fixed, paraffin-embedded samples of human ovarian cancer. Genome-wide segmentation data consisting of the log2 ratio (log2R) and B allele frequency...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28734796
DOI: 10.1016/j.canlet.2017.07.013

Genes

BRAF
FGFR2
JAK2
KRAS
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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