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Article

Tumor evolution and chemoresistance in ovarian cancer

30 Aug 2018

Abstract excerpt

Development of novel strategies to overcome chemoresistance is central goal in ovarian cancer research. Natural history of the cancer development and progression is being reconstructed by genomic datasets to understand the evolutionary pattern and direction. Recent studies suggest that intra-tumor heterogeneity (ITH) is the main cause of treatment failure by chemoresistance in many types of cancers including...

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PMID: 30246154
DOI: 10.1038/s41698-018-0063-0

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