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Evolutionary perspectives, heterogeneity and ovarian cancer: a complicated tale from past to present

3 Jun 2022

Abstract excerpt

Ovarian cancer is composed of a complex system of cells best described by features such as clonal evolution, spatial and temporal genetic heterogeneity, and development of drug resistance, thus making it the most lethal gynecologic cancer. Seminal work on cancer as an evolutionary process has a long history; however, recent cost-effective large-scale molecular profiling has started to provide novel insights...

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PMID: 35659345
DOI: 10.1186/s13048-022-01004-1

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