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Article

Evaluating Tumor Evolution via Genomic Profiling of Individual Tumor Spheroids in a Malignant Ascites.

Scientific reports - 24 Aug 2018

Kim Sungsik, Kim Soochi, Kim Jinhyun, Kim Boyun, Kim Se Ik, Kim Min A, Kwon Sunghoon, Song Yong Sang

Abstract excerpt

Epithelial ovarian cancer (EOC) is a silent but mostly lethal gynecologic malignancy. Most patients present with malignant ascites and peritoneal seeding at diagnosis. In the present study, we used a laser-aided isolation technique to investigate the clonal relationship between the primary tumor and tumor spheroids found in the malignant ascites of an EOC patient. Somatic alteration profiles of ovarian...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30143682
DOI: 10.1038/s41598-018-31097-y
PMCID: PMC6109089

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