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Article

Structures of the CRISPR genome integration complex.

Science (New York, N.Y.) - 15 Sept 2017

Wright Addison V, Liu Jun-Jie, Knott Gavin J, Doxzen Kevin W, Nogales Eva, Doudna Jennifer A

Abstract excerpt

CRISPR-Cas systems depend on the Cas1-Cas2 integrase to capture and integrate short foreign DNA fragments into the CRISPR locus, enabling adaptation to new viruses. We present crystal structures of Cas1-Cas2 bound to both donor and target DNA in intermediate and product integration complexes, as well as a cryo-electron microscopy structure of the full CRISPR locus integration complex, including the accessory...

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Identifiers

PMID: 28729350
DOI: 10.1126/science.aao0679
PMCID: PMC5748385

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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