Article
Structure of the Cmr2-Cmr3 subcomplex of the Cmr RNA silencing complex.
Structure (London, England : 1993) - 5 Mar 2013
Shao Yaming, Cocozaki Alexis I, Ramia Nancy F, Terns Rebecca M, Terns Michael P, Li Hong
Abstract excerpt
The Cmr complex is an RNA-guided effector complex that cleaves invader RNA in the prokaryotic immune response mediated by the CRISPR (Clustered Regularly Interspaced Short Palindromic Repeat)-Cas system. Here, we report the crystal structure of a Cmr subcomplex containing Cmr2 (Cas10) and Cmr3 subunits at 2.8 Å resolution. The structure revealed a dual ferredoxin fold and glycine-rich loops characteristic of...
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