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Article

Nucleic acid binding surface and dimer interface revealed by CRISPR-associated CasB protein structures.

FEBS letters - 16 Nov 2012

Nam Ki Hyun, Huang Qingqiu, Ke Ailong

Abstract excerpt

The CRISPR system is an adaptive RNA-based microbial immune system against invasive genetic elements. CasB is an essential protein component in Type I-E Cascade. Here, we characterize CasB proteins from three different organisms as non-specific nucleic acid binding proteins. The Thermobifida fusca CasB crystal structure reveals conserved positive surface charges, which we show are important for its nucleic acid...

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Identifiers

PMID: 23079036
DOI: 10.1016/j.febslet.2012.09.041
PMCID: PMC3878058

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Source receipt: pubmed, retrieved 7 Sept 2026.

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