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Article

Dynamics and energetics of the mammalian phosphatidylinositol transfer protein phospholipid exchange cycle.

The Journal of biological chemistry - 1 Sept 2017

Grabon Aby, Orłowski Adam, Tripathi Ashutosh, Vuorio Joni, Javanainen Matti, Róg Tomasz, Lönnfors Max, McDermott Mark I, Siebert Garland, Somerharju Pentti, Vattulainen Ilpo, Bankaitis Vytas A

Abstract excerpt

Phosphatidylinositol-transfer proteins (PITPs) regulate phosphoinositide signaling in eukaryotic cells. The defining feature of PITPs is their ability to exchange phosphatidylinositol (PtdIns) molecules between membranes, and this property is central to PITP-mediated regulation of lipid signaling. However, the details of the PITP-mediated lipid exchange cycle remain entirely obscure. Here, all-atom molecular...

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Identifiers

PMID: 28718450
DOI: 10.1074/jbc.M117.791467
PMCID: PMC5582838

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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