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Article

Free Energy Landscape of Lipid Interactions with Regulatory Binding Sites on the Transmembrane Domain of the EGF Receptor.

The journal of physical chemistry. B - 25 Aug 2016

Hedger George, Shorthouse David, Koldsø Heidi, Sansom Mark S P

Abstract excerpt

Lipid molecules can bind to specific sites on integral membrane proteins, modulating their structure and function. We have undertaken coarse-grained simulations to calculate free energy profiles for glycolipids and phospholipids interacting with modulatory sites on the transmembrane helix dimer of the EGF receptor within a lipid bilayer environment. We identify lipid interaction sites at each end of the...

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Share to ErbB Receptors
Share to Lipid Bilayers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Molecular Dynamics Simulation

Share to Phosphatidylinositol 4,5-Diphosphate

Share to Protein Interaction Domains and Motifs

Share to Protein Multimerization

Share to Protein Structure, Secondary

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Source

Open in PubMed Open full text

Identifiers

PMID: 27109430
DOI: 10.1021/acs.jpcb.6b01387
PMCID: PMC5002933

Genes

EGFR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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