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Article

Structure-function analysis of human [corrected] phosphatidylinositol transfer protein alpha bound to phosphatidylinositol.

Structure (London, England : 1993) - 1 Feb 2004

Tilley Sarah J, Skippen Alison, Murray-Rust Judith, Swigart Philip M, Stewart Albert, Morgan Clive P, Cockcroft Shamshad, McDonald Neil Q

Abstract excerpt

Phosphatidylinositol transfer protein alpha (PITPalpha) selectively transports and promotes exchange of phosphatidylinositol (PI) and phosphatidylcholine (PC) between lipid bilayers. In higher eukaryotes PITPalpha is required for cellular functions such as phospholipase C-mediated signaling, regulated exocytosis, and secretory vesicle formation. We have determined the crystal structure of human PITPalpha bound to...

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Identifiers

PMID: 14962392
DOI: 10.1016/j.str.2004.01.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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