Article
Structural insights into assembly and regulation of the plasma membrane phosphatidylinositol 4-kinase complex.
Developmental cell - 13 Jan 2014
Wu Xudong, Chi Richard J, Baskin Jeremy M, Lucast Louise, Burd Christopher G, De Camilli Pietro, Reinisch Karin M
Abstract excerpt
Plasma membrane PI4P helps determine the identity of this membrane and plays a key role in signal transduction as the precursor of PI(4,5)P2 and its metabolites. Here, we report the atomic structure of the protein scaffold that is required for the plasma membrane localization and function of Stt4...
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