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Article

The RIT1 C-terminus associates with lipid bilayers via charge complementarity.

Computational biology and chemistry - 1 Apr 2021

Migliori Amy D, Patel Lara A, Neale Chris

Abstract excerpt

RIT1 is a member of the Ras superfamily of small GTPases involved in regulation of cellular signaling. Mutations to RIT1 are involved in cancer and developmental disorders. Like many Ras subfamily members, RIT1 is localized to the plasma membrane. However, RIT1 lacks the C-terminal prenylation that helps many other subfamily members adhere to cellular membranes. We used molecular dynamics simulations to examine...

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Identifiers

PMID: 33517146
DOI: 10.1016/j.compbiolchem.2021.107437

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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