Article
C5 nephritic factors drive the biological phenotype of C3 glomerulopathies.
Kidney international - 1 Nov 2017
Marinozzi Maria-Chiara, Chauvet Sophie, Le Quintrec Moglie, Mignotet Morgane, Petitprez Florent, Legendre Christophe, Cailliez Mathilde, Deschenes Georges, Fischbach Michel, Karras Alexandre, Nobili Francois, Pietrement Christine, Dragon-Durey Marie-Agnes, Fakhouri Fadi, Roumenina Lubka T, Fremeaux-Bacchi Veronique
Abstract excerpt
C3 Glomerulopathies, which include Dense Deposit Disease and C3 Glomerulonephritis, are associated with genetic and acquired dysregulation of the C3 convertase alternative pathway of complement. The potential role of the activation of the C5 convertase has not been studied extensively. Here we analyzed IgG samples from patients with C3 Glomerulopathies to identify circulating autoantibodies that stabilize the C3...
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