Article

Monoclonal nephritic factors reveal insights into C3 convertase dynamics and dysregulation

2026-06-12

Abstract excerpt

C3- and C5-nephritic factors are potent but poorly understood autoantibodies that dysregulate complement convertases. To date, their underlying mechanisms of action, epitopes, and sequences remain unknown. To address this knowledge gap, we immune profiled B cells from a nephritic factor-positive C3 glomerulopathy patient and identified the first monoclonal C3- and C5-nephritic factors. We present the structure of...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b6f701e9-1061-5ba1-9bfe-c567f9acad51
DOI: 10.64898/2026.06.11.731599

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Monoclonal nephritic factors reveal insights into C3 convertase dynamics and dysregulationDOI 10.64898/2026.06.11.731599Read

Defining Nephritic Factors as Diverse Drivers of Systemic Complement Dysregulation in C3 GlomerulopathySemantic proximity Read

C5 nephritic factors drive the biological phenotype of C3 glomerulopathies.Semantic proximity Read

C3 Glomerulopathy: A Current Perspective in an Evolving LandscapeSemantic proximity Read

Acquired and genetic determinants of disease phenotype and therapeutic strategies in C3 glomerulopathy and immunoglobulin-associated MPGNSemantic proximity Read

C3 glomerulopathy: a kidney disease mediated by alternative pathway deregulationSemantic proximity Read

Complement inhibition in C3 glomerulopathy.Semantic proximity Read

Challenges in IgA Nephropathy Management: An Era of Complement InhibitionSemantic proximity Read

Glomerular disease: Functional consequences of C5 nephritic factors in C3 glomerulopathies.Semantic proximity Read

C3 glomerulopathy: what's in a name?Semantic proximity Read

C3 Glomerulopathy: Ten Years' Experience at Mayo Clinic.Semantic proximity Read

Complement is activated by elevated IgG3 hexameric platforms and deposits C4b onto distinct antibody domainsSemantic proximity Read

C3 glomerulonephritis: clinicopathological findings, complement abnormalities, glomerular proteomic profile, treatment, and follow-up.Semantic proximity Read