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Article

Overactivity of Alternative Pathway Convertases in Patients With Complement-Mediated Renal Diseases.

Frontiers in immunology - 1 Jan 2018

Michels Marloes A H M, van de Kar Nicole C A J, Okrój Marcin, Blom Anna M, van Kraaij Sanne A W, Volokhina Elena B, van den Heuvel Lambertus P W J

Abstract excerpt

Overactivation of the alternative pathway of the complement system is associated with the renal diseases atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G). C3 nephritic factors (C3NeF) play an important role in C3G pathogenesis by stabilizing the key enzymatic complex of complement, the C3 convertase. However, the reliability of assays detecting these autoantibodies is limited. Therefore, in...

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Identifiers

PMID: 29670616
DOI: 10.3389/fimmu.2018.00612
PMCID: PMC5893837

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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