Article
C3 glomerulopathy: the genetic and clinical findings in dense deposit disease and C3 glomerulonephritis.
Seminars in thrombosis and hemostasis - 1 Jun 2014
Xiao Xue, Pickering Matthew C, Smith Richard J H
Abstract excerpt
C3 glomerulopathy (C3G) defines a group of very rare renal diseases in which dysregulation of the alternative and terminal complement pathways plays a pivotal pathogenic role. Dysregulation is driven by genetic and/or acquired defects, with interindividual variability giving rise to two broad subtypes of C3G-dense deposit disease (DDD) and C3 glomerulonephritis (C3GN). Patient evaluation should include genetic...
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