Article
Different Aspects of Classical Pathway Overactivation in Patients With C3 Glomerulopathy and Immune Complex-Mediated Membranoproliferative Glomerulonephritis.
Frontiers in immunology - 1 Jan 2021
Michels Marloes A H M, van de Kar Nicole C A J, van Kraaij Sanne A W, Sarlea Sebastian A, Gracchi Valentina, Engels Flore A P T, Dorresteijn Eiske M, van der Deure Johannes, Duineveld Caroline, Wetzels Jack F M, van den Heuvel Lambertus P W J, Volokhina Elena B
Abstract excerpt
The rare and heterogeneous kidney disorder C3 glomerulopathy (C3G) is characterized by dysregulation of the alternative pathway (AP) of the complement system. C3G is often associated with autoantibodies stabilizing the AP C3 convertase named C3 nephritic factors (C3NeF). The role of classical pathway (CP) convertase stabilization in C3G and related diseases such as immune complex-mediated membranoproliferative...
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