Article
E2F1 somatic mutation within miRNA target site impairs gene regulation in colorectal cancer.
PloS one - 1 Jan 2017
Lopes-Ramos Camila M, Barros Bruna P, Koyama Fernanda C, Carpinetti Paola A, Pezuk Julia, Doimo Nayara T S, Habr-Gama Angelita, Perez Rodrigo O, Parmigiani Raphael B
Abstract excerpt
BACKGROUND: Genetic studies have largely concentrated on the impact of somatic mutations found in coding regions, and have neglected mutations outside of these. However, 3' untranslated regions (3' UTR) mutations can also disrupt or create miRNA target sites, and trigger oncogene activation or tumor suppressor inactivation. METHODS: We used next-generation sequencing to widely screen for genetic alterations...
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