Article
Landscape of MicroRNA Regulatory Network Architecture and Functional Rerouting in Cancer.
Cancer research - 4 Jan 2023
Hua Xu, Li Yongsheng, Pentaparthi Sairahul R, McGrail Daniel J, Zou Raymond, Guo Li, Shrawat Aditya, Cirillo Kara M, Li Qing, Bhat Akshay, Xu Min, Qi Dan, Singh Ashok, McGrath Francis, Andrews Steven, Aung Kyaw Lwin, Das Jishnu, Zhou Yunyun, Lodi Alessia, Mills Gordon B, Eckhardt S Gail, Mendillo Marc L, Tiziani Stefano, Wu Erxi, Huang Jason H, Sahni Nidhi, Yi S Stephen
Abstract excerpt
Somatic mutations are a major source of cancer development, and many driver mutations have been identified in protein coding regions. However, the function of mutations located in miRNA and their target binding sites throughout the human genome remains largely unknown. Here, we built detailed cancer-specific miRNA regulatory networks across 30 cancer types to systematically analyze the effect of mutations in...
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