Article

Systematic characterization of somatic mutation-mediated microRNA regulatory network perturbations

2020-06-02

Abstract excerpt

Somatic mutations are a major source of cancer development. Many driver mutations have been identified in protein coding regions. However, the function of mutations located in microRNAs (miRNAs) and their target binding sites along the human genome remains largely unknown. Here, we built comprehensive cancer-specific miRNA regulatory networks across 30 cancer types to systematically analyze the effect of mutations...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 582632df-223e-5400-bba2-f3e94e89bc0d
DOI: 10.1101/2020.06.02.128777

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Systematic characterization of somatic mutation-mediated microRNA regulatory network perturbationsDOI 10.1101/2020.06.02.128777Read

Landscape of MicroRNA Regulatory Network Architecture and Functional Rerouting in Cancer.Semantic proximity Read

Pan-Cancer analysis of somatic mutations in miRNA genesSemantic proximity Read

Pan-cancer analysis of somatic mutations in miRNA genes.Semantic proximity Read

Somatic mutations in miRNA genes in lung cancer – potential functional consequences of non-coding sequence variantsSemantic proximity Read

SomamiR: a database for somatic mutations impacting microRNA function in cancer.Semantic proximity Read

Cis-regulatory mutations associate with transcriptional and post-transcriptional deregulation of the gene regulatory program in cancersSemantic proximity Read

MicroRNAs and genomic variations: from Proteus tricks to Prometheus gift.Semantic proximity Read

Driver and passenger mutations in cancer.Semantic proximity Read

SomamiR 2.0: a database of cancer somatic mutations altering microRNA-ceRNA interactions.Semantic proximity Read

Systematic identification of significantly mutated regions reveals a rich landscape of functional molecular alterations across cancer genomesSemantic proximity Read

A pan-cancer atlas of somatic mutations in miRNA biogenesis genesSemantic proximity Read

A catalog of <i>cis</i> -regulatory mutations in 12 major cancer typesSemantic proximity Read