Article

Somatic mutations in miRNA genes in lung cancer – potential functional consequences of non-coding sequence variants

2019-03-15

Abstract excerpt

A growing body of evidence indicates that miRNAs may either drive or suppress oncogenesis. However, little is known about somatic mutations in miRNA genes. To determine the frequency and potential consequences of miRNA gene mutations, we analyzed whole exome sequencing datasets of ∼500 lung adenocarcinoma (LUAD) and ∼500 lung squamous cell carcinoma (LUSC) samples generated in the TCGA. Altogether, we identified >...

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Literature Corpus work: e5b1d147-37e0-5a10-9e60-7edb145af056
DOI: 10.1101/579011

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