Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GIGYF1/2 proteins use auxiliary sequences to selectively bind to 4EHP and repress target mRNA expression.

Genes & development - 1 Jun 2017

Peter Daniel, Weber Ramona, Sandmeir Felix, Wohlbold Lara, Helms Sigrun, Bawankar Praveen, Valkov Eugene, Igreja Cátia, Izaurralde Elisa

Abstract excerpt

The eIF4E homologous protein (4EHP) is thought to repress translation by competing with eIF4E for binding to the 5' cap structure of specific mRNAs to which it is recruited through interactions with various proteins, including the GRB10-interacting GYF (glycine-tyrosine-phenylalanine domain) proteins 1 and 2 (GIGYF1/2). Despite its similarity to eIF4E, 4EHP does not interact with eIF4G and therefore fails to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carrier Proteins
Share to Crystallization

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Eukaryotic Initiation Factor-4E

Share to Gene Expression Regulation

Share to HEK293 Cells

Share to Models, Molecular

Share to Protein Stability

Share to Protein Structure, Quaternary

Source

Open in PubMed Open full text

Identifiers

PMID: 28698298
DOI: 10.1101/gad.299420.117
PMCID: PMC5538437

Genes

GIGYF1
GIGYF2
GRB10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

GIGYF1/2 proteins use auxiliary sequences to selectively bind to 4EHP and repress target mRNA expression.PMID 28698298Read ↗

Critical contacts between the eukaryotic initiation factor 2B (eIF2B) catalytic domain and both eIF2beta and -2gamma mediate guanine nucleotide exchange.Semantic proximity Read ↗

The Structures of eIF4E-eIF4G Complexes Reveal an Extended Interface to Regulate Translation Initiation.Semantic proximity Read ↗

No evidence that human GIGYF2 interacts with growth factor receptor-bound protein 10 (GRB10): implication for human diseaseSemantic proximity Read ↗

No evidence that human GIGYF2 interacts with GRB10: implications for human disease.Semantic proximity Read ↗

Mextli proteins use both canonical bipartite and novel tripartite binding modes to form eIF4E complexes that display differential sensitivity to 4E-BP regulation.Semantic proximity Read ↗

Crystal structures of GCN2 protein kinase C-terminal domains suggest regulatory differences in yeast and mammals.Semantic proximity Read ↗

Repressor binding to a dorsal regulatory site traps human eIF4E in a high cap-affinity state.Semantic proximity Read ↗

Loss-of-function cancer-associated mutations in the EIF4G2 non-canonical translation initiation factorSemantic proximity Read ↗

Mutations in GCD11, the structural gene for eIF-2 gamma in yeast, alter translational regulation of GCN4 and the selection of the start site for protein synthesis.Semantic proximity Read ↗

GCD10, a translational repressor of GCN4, is the RNA-binding subunit of eukaryotic translation initiation factor-3.Semantic proximity Read ↗

Loss-of-function cancer-linked mutations in the EIF4G2 non-canonical translation initiation factor.Semantic proximity Read ↗

The beta/Gcd7 subunit of eukaryotic translation initiation factor 2B (eIF2B), a guanine nucleotide exchange factor, is crucial for binding eIF2 in vivo.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.