Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Critical contacts between the eukaryotic initiation factor 2B (eIF2B) catalytic domain and both eIF2beta and -2gamma mediate guanine nucleotide exchange.

Molecular and cellular biology - 1 Jul 2007

Mohammad-Qureshi Sarah S, Haddad Raphaël, Hemingway Elizabeth J, Richardson Jonathan P, Pavitt Graham D

Abstract excerpt

Diverse guanine nucleotide exchange factors (GEFs) regulate the activity of GTP binding proteins. One of the most complicated pairs is eukaryotic initiation factor 2B (eIF2B) and eIF2, which function during protein synthesis initiation in eukaryotes. We have mutated conserved surface residues wit...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Basic-Leucine Zipper Transcription Factors
Share to Catalysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cold Temperature

Share to Eukaryotic Initiation Factor-2B

Share to Guanine Nucleotides

Share to Mutant Proteins

Share to Protein Subunits

Source

Open in PubMed Open full text

Identifiers

PMID: 17526738
DOI: 10.1128/MCB.00495-07
PMCID: PMC1951959

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17526738-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Critical contacts between the eukaryotic initiation factor 2B (eIF2B) catalytic domain and both eIF2beta and -2gamma mediate guanine nucleotide exchange.PMID 17526738Read ↗

Homologous segments in three subunits of the guanine nucleotide exchange factor eIF2B mediate translational regulation by phosphorylation of eIF2.Semantic proximity Read ↗

The beta/Gcd7 subunit of eukaryotic translation initiation factor 2B (eIF2B), a guanine nucleotide exchange factor, is crucial for binding eIF2 in vivo.Semantic proximity Read ↗

Mutations in GCD11, the structural gene for eIF-2 gamma in yeast, alter translational regulation of GCN4 and the selection of the start site for protein synthesis.Semantic proximity Read ↗

PKR and GCN2 kinases and guanine nucleotide exchange factor eukaryotic translation initiation factor 2B (eIF2B) recognize overlapping surfaces on eIF2alpha.Semantic proximity Read ↗

eIF2β is critical for eIF5-mediated GDP-dissociation inhibitor activity and translational control.Semantic proximity Read ↗

Structure of the catalytic fragment of translation initiation factor 2B and identification of a critically important catalytic residue.Semantic proximity Read ↗

eIF2B promotes eIF5 dissociation from eIF2*GDP to facilitate guanine nucleotide exchange for translation initiation.Semantic proximity Read ↗

GIGYF1/2 proteins use auxiliary sequences to selectively bind to 4EHP and repress target mRNA expression.Semantic proximity Read ↗

Mutations in elongation factor 1beta, a guanine nucleotide exchange factor, enhance translational fidelity.Semantic proximity Read ↗

Insights into the architecture of the eIF2Bα/β/δ regulatory subcomplex.Semantic proximity Read ↗

Crystal structures of GCN2 protein kinase C-terminal domains suggest regulatory differences in yeast and mammals.Semantic proximity Read ↗

Molecular basis for the interactions of eIF2β with eIF5, eIF2B, and 5MP1 and their regulation by CK2Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.