Article
GCD10, a translational repressor of GCN4, is the RNA-binding subunit of eukaryotic translation initiation factor-3.
Genes & development - 15 Jul 1995
Garcia-Barrio M T, Naranda T, Vazquez de Aldana C R, Cuesta R, Hinnebusch A G, Hershey J W, Tamame M
Abstract excerpt
GCN4 mRNA is translated by a reinitiation mechanism involving four short upstream open reading frames (uORFs) in its leader sequence. Decreasing the activity of eukaryotic initiation factor-2 (eIF-2) by phosphorylation inhibits general translation in yeast but stimulates GCN4 expression by allowi...
Topics
- Amino Acid Sequence
- Binding Sites
- Chromosome Mapping
- Cloning, Molecular
- DNA-Binding Proteins
- Eukaryotic Initiation Factor-3
- Fungal Proteins
- Genes, Fungal
- Models, Genetic
- Molecular Sequence Data
- Mutation
- Open Reading Frames
- Peptide Initiation Factors
- Protein Biosynthesis