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Article

No evidence that human GIGYF2 interacts with GRB10: implications for human disease.

Life science alliance - 1 Sept 2025

Choi Jung-Hyun, Shpilman Israel, Mahmood Niaz, Farhangmehr Shaghayegh, Braunschweig Ulrich, Cruz Nathalia Gomide, Luo Jun, Ladak Reese Jalal, Pistofidis Angelos, Ragoussis Jiannis, Schmeing T Martin, Jafarnejad Seyed Mehdi, Blencowe Benjamin J, Sonenberg Nahum

Abstract excerpt

GIGYF2 (growth factor receptor-bound protein 10 [GRB10]-interacting GYF [glycine-tyrosine-phenylalanine] protein 2) reduces mRNA stability and translation via microRNAs, ribosome quality control, and several RNA-binding proteins. GIGYF2 was first identified in mouse cell lines as an interacting partner with GRB10, which binds to the insulin receptor and the insulin-like growth factor receptor 1. Mutations in the...

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Source

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Identifiers

PMID: 40523800
DOI: 10.26508/lsa.202503334
PMCID: PMC12171015

Genes

GIGYF2
GRB10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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No evidence that human GIGYF2 interacts with GRB10: implications for human disease.PMID 40523800Read ↗

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