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Article

Repressor binding to a dorsal regulatory site traps human eIF4E in a high cap-affinity state.

The EMBO journal - 15 Jul 1999

Ptushkina M, von der Haar T, Karim M M, Hughes J M, McCarthy J E

Abstract excerpt

Eukaryotic translation initiation involves recognition of the 5' end of cellular mRNA by the cap-binding complex known as eukaryotic initiation factor 4F (eIF4F). Initiation is a key point of regulation in gene expression in response to mechanisms mediated by signal transduction pathways. We have investigated the molecular interactions underlying inhibition of human eIF4E function by regulatable repressors called...

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Identifiers

PMID: 10406811
DOI: 10.1093/emboj/18.14.4068
PMCID: PMC1171482

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Repressor binding to a dorsal regulatory site traps human eIF4E in a high cap-affinity state.PMID 10406811Read ↗

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The C terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylation.Semantic proximity Read ↗

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